Since the advent of Viagra tablets online, there has been a marked improvement in the treatment of men who are suffering from erectile dysfunction. However, this is not without its own downside, as a lot of men, even without any definitive diagnosis of ED, now seek to buy Viagra online without prescription, if they as much as believe their erection is not strong enough.
The proliferation of internet sites that offer to service the needs of those who want to buy Viagra cheap deals has in no small means added to this problem. This practice not only smacks of crass disregard to the prescription plan for the drug, but also poses a great danger to these people.
Only recently, a report emanating from Washington showed that dozens of men who used Viagra and other impotence drugs experienced loss of vision. The Food and Drug Administration, the regulatory body probing into the report, cautioned that the loss of vision might be linked to the illnesses that cause impotence.
In an apparent bid to stem this tide, the FDA announced that it was in discussions with the makers of the oral erectile dysfunction treatments – Viagra, Levitra and Cialis – to enlighten the public, by way of including in the label, on the rare cases of varying loss of vision. The manufacturer of Cialis, in an apparent show of solidarity to the course, has already included a one-line message to that effect.
The topical reason for the discussion, however, is known as non-arteritic anterior ischaemic optic neuropathy, NAION, a loss of vision that occurs when there is a blockage in the blood supply to the optic nerve. According to the report submitted to the FDA, of the 43 vision loss, 38 cases were to do with Viagra users, while 4 and 1 were to do with Cialis and Levitra. The numbers were representative of such cases of rare side effects, if the over twenty million users of Viagra users were to be considered, according to a spokeswoman for Pfizer, the pharmaceutical company that manufactures the drug. Complicating this issue is the question of NIAON, which is believed to be among the leading causes of sudden vision loss in older people. Statistically, between 1,000 and 6,000 people lose their sites yearly due to NAION. ‘Statistics or not, the issue still has to be given serious attention,’ opined Cruzan.
The issue couldn’t have come up at a more controversial time when the drug industry and federal regulators have been targeted for criticisms for their presumed laxity in ensuring the safety of drugs in the market. The pullout of its potentially fatal pain-reliving drug, Vioxx, from the market by Merk and Co. (MRK) the year before piled up enough pressure on the FDA to investigate the recent vision loss incident.
A lot of money is at stake. And Pfizer’s recent quarterly filing with the Security and Exchange Commission, which showed a 5 percent rise to 438 million dollars, witnessed a downturn with the side effects controversy; the value of their stock losing 55 cents at the close of the day.
Viagra and the two other oral erectile dysfunction treatments are very successful drugs that have brought about a revolution in the treatment of ED. However, they already come with serious warnings to their users: The drugs are not to be used by men who are on any form of nitrate prescriptions, and men, already with heart conditions, whose doctors have warned that engaging in sexual intercourse would be too much exertion for them. The drugs manufacturers also warned about temporary visual change in the form of having difficulty distinguishing between blue and green.
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Just before the official launch of Viagra, the medication that treats patients with erectile dysfunction, the Gay and Lesbian Medical Association scheduled a meeting with representatives of Pfizer Inc., in San Francisco. The purpose of the meeting was to discuss concerns over the effect of Viagra on the health of some gay and bisexual men.
GLMA was of the opinion that such concerns were of great importance to necessitate health care provision to providers and members of the gay and lesbian community with vital issues about Buying Viagra cheap deals. Further interactions between GLMA and Pfizer Inc. were expected as more information on the issues became known.
Viagra and Protease Inhibitors
Specific studies on the interaction of Viagra with protease inhibitors had not been carried out then. As a result, HIV-positive men who were on protease inhibitors prescription and who were considering using the best Viagra tablets were advised to review carefully what was then known about the drug with their physician. As at then, it was not known whether the efficacy of protease inhibitors would be reduced by Viagra. Thus, caution was advocated, and patients were told to be carefully monitored. It was believed that the side-effects of Viagra might be enhanced by protease inhibitors, such as flushing and headaches. The metabolism of Viagra (sildenafil citrate) is by the cythochrome p450 enzyme in the liver. The medications that inhibit the cythochrome p450 enzyme may affect the metabolism of Viagra, specifically the 3A4 isoform. Included in this group of cythochrome inhibitors are medications commonly used by patients who are HIV positive, such as protease inhibitors and some antibiotics which include the newer macrolides, e.g. Azithromycin or Clarithromycin. Worthy of mention is that Pfizer was as at the time completing studies on Azithromycin and hoped to be able to furnish information on the drug. Also studies showed that Erythromycin taken at conventional doses increased the concentration of Viagra in the serum.
Viagra and protease inhibitors and/or antibiotics when taken together, it was said, could cause an increase in Viagra plasma concentrations. Medical providers were thus advised to consider starting their patients who were taking medications that inhibit cytochrome p450 3A4 at the lowest possible Viagra dose of 25 mg. According to the approved package insert of the drug, the efficacy and incidence of adverse events of the drug may be increased by higher plasma levels. GLMA, however, urged the medical providers to monitor patients carefully for possible drug-drug interactions, as in the case of any newly-approved drugs which could be taken by patients with HIV.
Make sure you buy Viagra online safely, because it is a major advancement in the treatment of erectile dysfunction, notwithstanding, people living with HIV and their providers were told to always remember that erectile dysfunction was adducible to numerous factors, ranging from depression to low levels of testosterone.
Viagra and Nitrates
Considering that Viagra produces its beneficial effects by acting through the nitric oxide/cGMP pathway, it was believed that the drug may potentiate the massive lowering of blood when taken in combination with nitrates in any form (particularly inhaled forms such as “poppers” or amyl nitrate). Taking the drug with nitrate is therefore contraindicated. "Poppers" are known to dilate blood vessels, and when taken with Viagra could synergistically lower the blood pressure, which could be serious potentially or even become fatal. Medical providers and HIV-positive patients were advised to discuss all forms of recreational drugs, in particular the use of any form of inhaled nitrates, before any Viagra could be prescribed. Concurrent use of "poppers" and Viagra could result in sudden and marked lowering of blood pressure, which can be potentially serious or even fatal. Medical providers and patients should discuss all recreational drug use, especially the use of "poppers" or other forms of inhaled nitrates, prior to prescribing Viagra. Also every physician prescribing Viagra was told to discuss safe sex with their patients.
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I wish I could just die. These are the thoughts of Ron Hanson, a man experiencing a type of impotence known as erectile dysfunction, which is simply the inability of a man to attain or sustain an erection long enough to achieve sexual penetration. In his early forties, Ron (not real name) could be considered too young by many to be affected by this problem. When Ron finds out that he has ED, he, in keeping in line with men before him who were experiencing similar problem, he decides to bottle up his problem to himself.
After seven years of suffering in silence, Ron summons up courage to discuss his problem with a urologist. This decision, of course, is in no small part swayed by the recent breakthrough in the treatment of ED with the discovery of Viagra. Filled with a new surge of hope, after he buys Viagra cheap online, Ron gets himself a girl to test the efficacy of his magic acquisition.
But alas, on the appointed day when Ron is supposed to put his scourge of impotence to bed, his penis refuses to rise; the magic pill has failed him.
The astonishing success story associated with the use of real Viagra tablets since hitting the market as an ED treatment, means that a lot of men who are plagued by the ED scourge are now filled with hope. Many now besiege their doctors for prescription, while numerous internet sites have sprung up to attend to the needs of those who want to buy Viagra online without prescription.
Erectile dysfunction is a medical condition commonly caused by diabetes, heart disease and psychiatric conditions. Another factor that makes a man prone to erectile dysfunction is the effect of prostrate cancer surgery on the man.
When a man is sexually aroused, he experiences a rush of blood to his penis which results in erection. A man who is suffering from ED, however, would not encounter this normal pathway. This is because his ‘in’ vessels or arteries are too narrow, or because his ‘out’ muscles or veins are such that blood drains quickly through them, according to the words of Arnold Aigen, MD, a urologist with Camino Medical Group, Sunnyvale, Calif. There are times when Viagra, the therapeutic drug that releases nitric oxide into the corpus cavernosum of the penis in order for erection to take place, may not be effective enough because the arteries are too narrow.
The narrow arteries may have been the reason for the failure of the drug to work in Ron’s case. This is notwithstanding the headache Ron had to bear because he used the blue pill. Fortunately, when Viagra failed to work for him, Ron discovered alternatives which worked.
Alprostadil as an effective alternative to Viagra
Alpostradil is a medication – that has to be taken either alone or in combination with other drugs like papaverine and phentolamine, according to experts – that widens the arteries. As an ED drug, the drug can produce an erection within ten minutes of administration, which can last up to one hour. Teresa Beam, a urologist with the Grey Clinic, was quick to point out to the disadvantages of using the drug, primary of which is the injection mode of administration. She went on to highlight priapism – a case of prolonged painful erection – as a side effect of the drug.
To make the drug attractive to men who are averse to injection, the drug is now available as a suppository in pelleted form to be inserted into the tip of the penis and absorbed via the urethral lining. Taking this way, according to the Impotence World Association, the drug can produce erection that can last from 30 to 60 minutes.
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