Viagra is a drug that has achieved unparalleled success in the treatment of erectile dysfunction. Originally formulated and tested for the treatment of angina pectoris and hypertension by a group of pharmaceutical chemists, Viagra tablets were later found out to be potent in producing erection among a group of men who were believed to be impotent.
For a drug whose discovery could be described as serendipitous at best, the success story is such that a lot of people are still joining the Viagra revolution.
Anyone who wants to buy Viagra online safely would be better served understanding the mechanism of action of the drug.
Viagra tablets are primarily constituted of Sildenafil citrate, a drug which dilates the blood vessels to facilitate an increased flow of blood, like high blood pressure medications. Capable of opening up the blood vessels to carry more blood to the penis, real Viagra tablets not only help produce erection, but can help maintain this erection for around four hours.
This is made possible because Sildenafil citrate facilitates the relaxation of the smooth muscles through the release of nitric oxide (NO) into the corpus cavernosum of the penis.
The relaxation of the smooth muscles occurs when the NO binds to the receptors of the enzyme guanylate cyclase which enables the increased levels of cyclic guanosine monophosphate (cGMP), resulting in increased inflow of blood to the corpus cavernosum and an erection.
Sildenafil citrate potently and selectively inhibits cGMP specific phosphodiesterase type 5 (PDE5), which degrades cGMP. Because sildenafil citrate is similar in molecular structure to cGMP, it can act as a competitive binding agent of PDE5 in the corpus cavernosum, thereby allowing for levels of the cGMP to be raised and better erections.
Sildenafil citrate, metabolised by liver enzymes and excreted by both the liver and kidney, should not cause an erection when there is no sexual stimulation, because the NO/cGMP system can not be activated.
The absorption of Sildenafil Citrate is reduced; the time taken to reach the maximum, when taken with a meal rich in fatty contents.
Approved over ten years ago by the FDA as a prescription drug for the oral treatment of ED, the vast number of internet sites making bargain offers to those who want to buy Viagra cheap online have increased the incident of self-medication. However, any person who wants to buy Viagra online without prescription is advised to exercise some caution before taking the decision. Anyone who wants to buy Viagra online next day delivery should note that sildenafil citrate, like any medication, is capable of synergistically interacting with other drugs.
HIV positive patients who are taking protease inhibitors, for example, are advised to seek consultation with their doctors. This is because protease inhibitors can multiply the plasma levels of sildenafil through the prevention of its metabolism. An increased plasma level of sildenafil can equally increase the incidence and severity of side-effects of the drug.
Patients using protease inhibitors are usually advised to limit their use of sildenafil to no more than 25 mg dose every 48 hours.
Also, the combined use of sildenafil and an alpha blocker – drugs used to treat benign prostatic hyperplasia, Raynaud's disease and high blood pressure – could result in a drop of the blood pressure.
To boot, studies have shown that some complications could occur when using the diamond-shaped blue pill and, as such, must be taken with precaution.
Because Viagra tablets are such a complex medication, some medical conditions exist that make taking the drug impossible for some patients. Stroke patients, for example, are advised strongly against taking the blue pills.
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Real Viagra tablets, the potent phosphodiesterase type 5 (PDE5) inhibitor, is a popular drug whose sale is yet to be paralleled in the oral ED treatment market. The internet, as a non-traditional source of obtaining the drug, has played a big part in making the drug available to a great number of people who want to buy Viagra cheap. However, before making the decision to buy Viagra online with no prescription, it is pertinent to note that self-medication is not always an advisable route to consider for a prescription drug. Viagra tablets, like every other medication, can have severe side effects.
The United States Food & Drug Administration (FDA), as recently as October 2007, requested that changes should be made to the label of Viagra. The changes, which include warnings about sudden hearing loss associated with the use of the drug, were coming hard on the heels of the 29 reports received by the FDA about patients who experienced such loss within hours to two days of taking best Viagra tablets.
The majority of men who buy Viagra online safely are older, and it is not unusual for this generation of users to experience hearing loss. However, the process of hearing loss among this class is almost always gradual, and sudden loss of hearing is considered uncommon.
According to the FDA, the reported cases of sudden loss of hearing among the users of Viagra tablets UK were accompanied by tinnitus, a ringing or roaring in the inner ear, and dizziness. While most of the reported cases involved loss of hearing in one ear, a third of these were temporary.
After the pre-approval testing for Viagra, in which there were reported cases of hearing loss, a one-word mention of “deafness” as a potential side effect was included on the former Viagra label. However, the new Viagra label carries warning on both the “Adverse Reactions” and “Precautions” sections of the label. The new “Precautions” section advice doctors to warn their patients about the possibility of experiencing hearing loss as one of the side effects for using the drugs. In the same vein, the new “Adverse Reactions” section warns users of the possibility of hearing loss from the drug.
Vision loss through Viagra use.
The likelihood of Viagra engendering non-arteritic ischaemic optic neuropathy, NAION, was first raised by Howard Pomeranz, MD, an eye expert at the University of Minnesota. This was after he reported the case of how a man developed NAION not too long after he took Viagra. Since then, several other Viagra-induced NAION cases have been reported.
According to a study published in the Journal of Neuro-Ophthalmology, Pomeranz highlighted seven new cases, which brought the total of such cases to 14. On the 26tof May of the same year, the FDA disclosed to the CBS News about its on-going investigation into similar reports in nearly 50 men.
Can NAION lead to permanent loss of vision?
In most cases, permanent loss of vision due to NAION does not occur. In fact, recent studies have shown that a surprisingly high number of NAION patients spontaneously recover on their own.
Researchers, in conducting studies on 100 or so men and women who were involved in a major trial sponsored by the National Eye Institute, found out that about 40 percent of NAION patients spontaneously had some marked improvement in their sights after three months. This was, indeed, a better result when compared to their counterparts who were made to undergo an experimental procedure to prevent further loss of their vision due to NAION.
Kay Dickersin, PhD, a professor of Community Health at Brown University who has being involved with the study, known as the Ischemic Optic Neuropathy Decompression Trial, gave a positive summary of the research when he said that the trial was much better than expected.
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Viagra, the popular drug manufactured by Pfizer, is a treatment for making men suffering from a kind of impotence known as erectile dysfunction achieve full and rock-hard erection. Since becoming available in the market, cheap Viagra tablets have gone on to record enormous success in not only treating the ED condition, but also solving emotional problems that could arise from the failure of a man to achieve the act of love.
In addition to this, real Viagra tablets, because of its ability to prolong erection through the slowing down of the rate at which blood flows out of the corpus cavernosum by constricting the veins and letting blood to be trapped inside the penis, are believed by many to prolong ejaculation.
For this reason, many people, who simply want to improve their performance in bed and are not suffering from any form of ED, now buy Viagra online with no prescription.
This obviously goes against the manufacturer’s plan for the drug to be used exclusively for the treatment of ED, and not as a definitive cure for other sexual dysfunctions.
The myth surrounding the drug as a cure for a number of sexual dysfunctions means more and more people are now buying Viagra cheap online, and what is more has seen numerous discussion sites on the issue being inundated with feelings about the drug actually increasing the size of the penis.
In one such discussion website, a respondent, in responding to the penile increase feeling, was categorical when he said that Viagra was not a penis enlargement pill, but was highly effective in inducing erection. The respondent, however, added that because Viagra tablets online can produce an erection that is harder than the one experienced by a man before he had erectile dysfunction, it is possible that the full erection the man experienced would be bigger than the partial erection he was having without using Viagra.
But this response has not done much to diminish the feelings of readers as dozens of reports about how the readers felt that their penises became thicker and longer after they used Viagra are being sent.
Below are some of the reports sent:
"After I used Viagra, my wife said that my penis was bigger than it has ever been."
"My partner observed I was both thicker and longer."
"Viagra has made my penis bigger and harder than ever before, and my come shoots faster farther than it has ever been."
"Since I started using Viagra, I last much longer than I used to. I’m also bigger and longer in size."
‘What is happening here?’ One would ask for the umpteenth time. Is it possible that Viagra, that erectile dysfunction drug that its maker, Pfizer, says is exclusively for the treatment of erectile dysfunction, actually increases the size of the penis?
If these reports are anything to go by, two things could be given as plausible explanation for them, and they only corroborate what has already been known. Because Viagra mostly gives a full erection, it is likely that the partial erection attained before the use of Viagra is not as big or as thick as when the erection becomes full. So, it is possible that the stretching of the penis to its full limit actually makes the men bigger. And it is also probable that the men are not actually bigger than they were before they started having the erectile problem, or they may in fact be bigger than they were since they started experiencing erectile dysfunction.
Finally, no clinical studies on this issue are known presently. And what is known could at best be described as anecdotal and postulational. However, the consistency of these reports means that the reports should not be ignored.
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