Sildenafil Citrate is generally known as the active ingredient in the world’s most popular Erectile Dysfunction (ED) drug: Viagra. It was originally developed as a cure for pulmonary arterial hypertension and angina pectoris by a group of pharmaceutical chemists working in Pfizer’s Kent Research facility. Because the drug was discovered not to be effective for angina, but however produced erection among a group of men who were believed to be impotent – surprisingly – Sildenafil Citrate was patented and approved by the United States Food and Drug Administration as the first oral treatment for erectile dysfunction in 1998.
After the normal practice of getting a prescription from the doctor, Viagra pills are typically obtained from reputable pharmacies. However, the proliferation of internet sites offering Viagra tablets for sale – most of them with little or no credible origins – has generally tipped the scales towards the tendency for people to buy Viagra online with no prescription.
What impact has Sildenafil Citrate played since its introduction into the ED market?
Before Viagra pills became available for sale, there were different drugs for the treatment of ED. Available treatment options for Erectile Dysfunction were largely unsatisfactory or inconvenient for use. As early as the 1980s, men suffering from ED were able to inject a drug, commonly Prostaglandin E1, in the corpus cavernosum of their penis (intracorporeal pharmotherapy). Another treatment involved the insertion of a prosthesis into the penis, with the aid of anaesthetics. However, these methods, despite being able to produce erection, were never going to be popular for a number of reasons which all bordered on being not an entirely satisfactory treatment. For instance, the injection of the corpus cavernosum with Prostaglandin E1, if the use is prolonged, could bring about the scarring of the penis. Also, the available drugs then, because there side effects and drug interactions were not well known, were not prescribed by physicians.
Fast forward the late 1990s, 1998 to be specific, the discovery of Sildenafil Citrate or Viagra, as it is more popularly known, did pierce through every existing barrier in the treatment of ED. Not only was the drug convenient for use – due to its amazingly simple oral route of administration – the extensive research carried out by Pfizer, Inc., the manufacturer of Viagra, ensured that who ever wanted to order Viagra tablets, would be doing so equipped with the knowledge of what to expect from its side effects.
The enormous success achieved by Pfizer, Inc., in the marketing of Viagra, to boot, has set a precedence that has concomitantly brought about an increased interest in research and studies on erectile dysfunction by pharmaceutical companies all over the world. These studies, in recent times, have thus far yielded positive results, as new drugs have been added to swell the ranks of drugs available in the ED market.
Explaining the mechanism of action of Sildenafil Citrate.
Sildenafil citrate is a known inhibitor of phosphodiesterase type 5 enzyme (PDE 5). So effective is this drug in inhibiting the enzyme – the enzyme degrades cyclic guanosine monophosphate (cGMP), that relaxes the smooth muscles (vasodilation) when raised in levels – that it exhibits this effect for approximately four hours.
This is possible because Sildenafil, as a structural analogue of cyclic guanosine monophosphate (cGMP), competitively binds with PDE 5, and the raised levels allows for the flow of blood into the corpus cavernosum and subsequent erection of the penis.
Sildenafil citrate, like most medications, produces some minor side effects. These include: stomach ache, dyspepsia, nasal congestion, etc. In addition, sildenafil citrate is contraindicated for some drugs. An example of such drug is the hypertension drugs, typically alpha blockers, which when taken together with Viagra tablets could reduce the blood pressure to a much fatal level.
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When a man is said to be impotent, the man is said to be suffering from a condition that makes him incapable of having an erection when he is sexually aroused. Though impotence or erectile dysfunction, as medical practitioners refer to it, is normally viewed as normal when it occurs occasionally, it becomes a problem, however, when the inability to achieve erection for sexual satisfaction or penetration becomes frequent. Quite distinct from other sexual dysfunctions – premature ejaculation, weak libido, etc. – in that sexual penetration might be attained in these other cases, ED is a common problem whose incidence increases with age.
Statistics have shown that the incidence of ED is on the rise, and it is on record that approximately 10 to 15 million men in the United States are believed to be impotent.
A further breakdown of this figure shows that slightly less than 4 percent of males between the age bracket of 30 to 45, approximately 7 percent between the ages of 45 and 55 years, about 25 percent at 65, and about 75 percent of male from 80 years and above, are affected by ED.
Impotence is classified as either primary or secondary, depending on the time of its commencement – primary and secondary. Primary impotence occurs when the genitals are faulty. Secondary impotence occurs when a man, who used to have a normal ability to attain erection, suddenly loses his erectile ability. Secondary impotence could occur either during adolescence or adulthood.
It is generally believed that most impotent cases had physical causes, which were often aggravated by psychological factors by the time treatment is sought.
The several types of physical treatment for impotence included the injection of a drug in the corpus cavernosum of the penis of men who were impotent (intracorporeal pharmotherapy), drugs administered through the oral or topical routes, etc. However, none of these drugs produced little satisfactory results. As problems, such as scarring as a result of prolong use – in the case of the injection – and lack of adequate information on the side effects and drug interactions by doctors – in the case of the drugs administered through the oral and topical routes – made these treatment methods unpopular.
However, the advent of Viagra tablets in 1998 – the first drug to be approved by the US Food and Drug Administration as the oral treatment of choice for ED – brought about a sea change in the treatment of ED.
Such is the popularity of this drug among men who buy Viagra online that even the introduction of other drugs into the market, which work similarly to Viagra, have been overshadowed by the magic blue pills.
This popularity is in no small part helped by the fact that anyone who buys Viagra online, it has long been established, would be doing so with the knowledge that Viagra tablets are effective inhibitors of the phosphodiesterase type 5 (PDE 5) enzyme. And like other PDE 5 inhibitors, sildenafil citrate, the active ingredient in Viagra, relaxes the smooth muscles. The relaxation of the smooth muscles is facilitated when the levels of cyclic guanosine monophosphate (cGMP), which is physiologically degraded by the PDE 5, are raised. The relaxation of the smooth muscles enables blood to flow into the corpus cavernosum of the penis, and subsequently makes the penis to enlarge and become stronger.
Available on the internet, and the proliferation of internet sites offering irresistible offers now mean that this non-traditional source of distribution is now the first option for the majority of those who want to buy Viagra cheap.
Viagra is the trademark of Pfizer Inc., the largest drug maker in the world.
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Viagra tablets, the major best selling drug formulated by Pfizer, Inc., have being significant in helping millions of men who suffer from erectile dysfunction to achieve the act of lovemaking. Since the discovery of the drug more than ten years ago – which could be described as serendipitous at best, because Sildenafil Citrate, the generic name for Viagra, was originally isolated by a group of pharmaceutical chemists who were running a trial test of the drug on a group of men suffering from angina pectoris and hypertension – the number of people who still buy Viagra online safely is remarkable. This is in no small part due to the enormous success recorded by the drug in helping people achieve very firm erection.
Viagra tablets are generally known to be potent inhibitors of the phosphodiesterase type 5 (PDE 5) enzyme. The inhibition of the PDE 5 enables the arterial walls to be dilated through a process known as vasodilation and allows for blood to flow into the corpus cavernosum of the penis. Key physiological reactions that also take place at the same time are the constriction of the veins that take blood away from the penis and the enhancement of the increased levels of cyclic guanosine monophosphate.
The latter reaction is very significant in the relaxation of the smooth muscles, vasodilation, while the former allows for the blood to be trapped inside the penis. The flow of blood to the penis increases the length of the penis and makes it firm, while the trapping of its flow ensures that erection is sustained for a considerable period of time.
The diamond-shaped blue pills are mainly available on prescription by doctors. However, the internet is proliferating the spread of this drug through irresistible offers that not only lure those who want to buy Viagra cheap, but also those who want to buy Viagra online without no prescription. Self-medication, as always, is not an advisable route to consider. Apart for the obvious health hazards inherent in this route, there is also the tendency for the people that self-medicate to develop some myths in justifying their decision.
For those who buy Viagra online, for instance, there is the tendency for them to believe that they are buying real Viagra tablets because the drug can enhance their sexual arousal, make them ejaculate more pleasurably, prolong their ejaculation.
For whatever reasons these people choose to buy Viagra tablets no prescription, it is pertinent to note that historically or scientifically, the belief that the blue pills might enhance these sexual functions might be mainly down to what could at best be described as placebo effect, that is a psychological sense of benefit the users of Viagra might have felt solely from the knowledge that they have used the drug.
The maker of Viagra tablets, to boot, has not been able to substantiate claims that their magic formulation can increase sexual desire or performance.
Is it true that Viagra makes ejaculation difficult?
Regardless of the fact that the maker of real Viagra tablets is yet to substantiate these claims, some people complain about how they have been finding it difficult to ejaculate after using Viagra. They claim that while they find it easy to achieve erection, their sensitivity reduces and reaching orgasm becomes a problem for them.
This could be a blessing for the numerous men who suffer from premature ejaculation, but becomes a problem for others who do not suffer from this condition.
A way of solving this problem is to start with low level administration of the drug. This way, the penis does not become too rigid and the sensitivity is not reduced.
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