An anti-impotence drug approved by the United States Food and Drug Administration and available by prescription in mid-April 1998 raised hopes for millions of men who suffer from a type of impotence known as erectile dysfunction, the inability to obtain and maintain an erection. Analysts expected Sildenafil Citrate, produced by Pfizer, Inc. under the name Viagra, to become one of the best-selling drugs in history.
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At the mention of erectile dysfunction, one could be forgiven if the only thing that comes to one’s mind is Viagra. Such is the popularity of this brand that close substitutes struggle to come out of the shadow of a drug that has imprinted its name in the minds of a greater proportion of a sexually conscious populace. Considering that the discovery of the drug could at best be described as serendipitous, this is by no means an ordinary feat by any stretch of the imagination.
Synthesised by a group of pharmaceutical chemists working at Pfizer’s Sandwich, Kent, research facility in the UK, Sildenafil was initially studied for use in hypertension and angina pectoris (a symptom of ischaemic heart disease). After the first clinical trials were conducted in Morrison Hospital, Swansea, it was discovered that Sildenafil was ineffective for angina. However, participants in the study noted a surprising side effect: the drug induced penile erection among men who were impotent. This discovery prompted the decision by Pfizer to market the drug for erectile dysfunction rather than for angina.
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Introduction
Since real Viagra tablets were approved in the US and became available as a prescription drug in the middle of April, 1998, and its subsequent success, there has been a renewed interest in the treatment of erectile dysfunction (ED), especially through the oral route of administration. A prominent drug in the market is Tadalafil – trade name: Cialis. A quick look at the ED drug market shows that a new drug, Vardenafil – trade name: Levitra – has jumped on the bandwagon. Judging by the potency of Viagra – Buy Viagra online next day delivery – and Levitra in treating patients with ED problem, both have become household names with the same mechanism of action in inhibiting phoshodiesterase and boosting the effects of nitric oxide, a chemical compound that is known to relax the penile musculature. There are however individual features that distinguish these drugs from one another.
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